Vargas claimed that this would be the last fight of his career regardless of the result. He warned Mayorga that he would not tolerate any insults from him like the ones he hurled at Oscar De La Hoya in their press conferences. Vargas stayed true to his promise when at the first official press conference for the fight, Mayorga said some offensive things towards Vargas and attempted to slap him. Vargas immediately jumped up from his seat and retaliated with punches and a brawl broke out between the two fighters' camps, though order was quickly restored. Vargas also recalled the time when Mayorga said Vargas was scared of him when he had defeated Javier Castillejo, then was stripped of his WBC light middleweight title rather than face Mayorga, who then defeated Michele Piccirillo for the vacant title. Ultimately the contestants faced off, and Mayorga defeated Vargas by majority decision on November 23, 2007. The scores were 113-113, 114-112, and 115-111. Crucially, Vargas was knocked down in the 1st round and again in the 11th round. Post-fight Ricardo Mayorga apologized to Vargas and the two forgave each other. Vargas officially declared his retirement soon after.