Verteporfin is transported in the plasma primarily by lipoproteins . Once verteporfin is activated by light in the presence of oxygen, highly reactive, short-lived singlet oxygen and reactive oxygen radicals are generated. Light activation of verteporfin results in local damage to neovascular endothelium , resulting in vessel occlusion . Damaged endothelium is known to release procoagulant and vasoactive factors through the lipo-oxygenase ( leukotriene ) and cyclooxygenase (eicosanoids such as thromboxane ) pathways, resulting in platelet aggregation , fibrin clot formation and vasoconstriction . Verteporfin appears to somewhat preferentially accumulate in neovasculature, including choroidal neovasculature. However, animal models indicate that the drug is also present in the retina . Therefore, there may be collateral damage to retinal structures following photoactivation including the retinal pigmented epithelium and outer nuclear layer of the retina. The temporary occlusion of the choroidal neovascularization (CNV) following VISUDYNE therapy has been confirmed in humans by fluorescein angiography .
Does this product still exist? Can you tell me where I might be able to find it online (or locally in N or central NJ)? I am trying to find it without success. I have at least 2 coats (gray on top, beige below, could be 2 coats each) of solid stain to remove from the deck floor. The gray layer is arborcoat water based (can was in garage when I bought the house, mixed July 2015). The stain hasn't failed, but I don't like the solid stain. I like the look of grayed/ weathered cedar, and I like to see the wood grain. I'm trying to remove the stain from the deck floor and looking for a clear(ish) stain to treat the wood once it's clean.