Upjohn developed a process for the large scale production of cortisone . The oxygen atom at the 11 position in this steroid is an absolute requirement for biological activity. There are however no known natural sources for starting materials that contain that feature. The only method for preparing this drug prior to 1952 was a lengthy synthesis starting from cholic acid isolated from bile. In 1952 two Upjohn biochemists, Dury Peterson and Herb Murray announced that they were able to introduce this crucial oxygen atom by fermentation of the steroid progesterone with a common mold of the genus Rhizopus . Over the next several years a group of chemists headed by John Hogg developed a process for preparing cortisone from the soybean sterol stigmasterol . The microbiological oxygenation is a key step in this process. 
There are many side effects associated with Winstrol that can occur in both male and female. In women, there are menstrual irregularities as well as clitoral enlargement. In rare cases, Cholestatic jaundice and hepatic necrosis and even death. Men often experience increased erections and even Phallic enlargement. An increase or decrease in libido occurs in both men and women. Other side effects occur with the central nervous system, breast, hair, skin, skeletal, edema, and the endocrine system. One of the main side effects is liver damage.